Title |
Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice
|
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Published in |
Arthritis Research & Therapy, September 2014
|
DOI | 10.1186/s13075-014-0445-9 |
Pubmed ID | |
Authors |
Waka Yokoyama, Hitoshi Kohsaka, Kayoko Kaneko, Matthew Walters, Aiko Takayasu, Shin Fukuda, Chie Miyabe, Yoshishige Miyabe, Paul E Love, Nobuhiro Nakamoto, Takanori Kanai, Kaori Watanabe-Imai, Trevor T Charvat, Mark ET Penfold, Juan Jaen, Thomas J Schall, Masayoshi Harigai, Nobuyuki Miyasaka, Toshihiro Nanki |
Abstract |
Biological drugs are effective in patients with rheumatoid arthritis (RA), but increase severe infections. The CC chemokine receptor (CCR) 9 antagonist was effective for Crohn's disease without critical adverse effects including infections in clinical trials. The present study was carried out to explore the pathogenic roles of chemokine (C-C motif) ligand (CCL) 25 and its receptor, CCR9, in autoimmune arthritis and to study if the CCR9 antagonist could be a new treatment for RA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 3% |
Unknown | 38 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 28% |
Student > Ph. D. Student | 5 | 13% |
Professor | 4 | 10% |
Student > Bachelor | 3 | 8% |
Student > Postgraduate | 3 | 8% |
Other | 6 | 15% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 26% |
Immunology and Microbiology | 10 | 26% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Agricultural and Biological Sciences | 2 | 5% |
Computer Science | 2 | 5% |
Other | 0 | 0% |
Unknown | 10 | 26% |