Title |
Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain
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Published in |
Veterinary Research, October 2017
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DOI | 10.1186/s13567-017-0469-7 |
Pubmed ID | |
Authors |
Thavamathi Annamalai, Chun-Ming Lin, Xiang Gao, Xinsheng Liu, Zhongyan Lu, Linda J. Saif, Qiuhong Wang |
Abstract |
We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20-29 days post-inoculation (dpi), all pigs were challenged with the PC21A strain. The S-INDEL-inoculated pigs had lower ileal IgA antibody secreting cells, serum IgA and neutralizing antibody titers compared with PC21A-inoculated pigs. No pigs in the PC21A-group developed diarrhea, whereas 81 and 100% of pigs in the S-INDEL and mock-groups had diarrhea post challenge, respectively. S-INDEL induced partial protective immunity against the original US PEDV strain. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 23% |
Student > Master | 6 | 19% |
Other | 5 | 16% |
Student > Bachelor | 4 | 13% |
Student > Ph. D. Student | 2 | 6% |
Other | 2 | 6% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 6 | 19% |
Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Agricultural and Biological Sciences | 3 | 10% |
Nursing and Health Professions | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 6 | 19% |
Unknown | 8 | 26% |