Title |
Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints
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Published in |
Arthritis Research & Therapy, September 2014
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DOI | 10.1186/s13075-014-0437-9 |
Pubmed ID | |
Authors |
Eugene Krustev, Allison Reid, Jason J McDougall |
Abstract |
During the progression of rheumatoid arthritis (RA), there are frequent but intermittent flares in which the joint becomes acutely inflamed and painful. Although a number of drug therapies are currently used to treat RA, their effectiveness is variable and side effects are common. Endocannabinoids have the potential to ameliorate joint pain and inflammation, but these beneficial effects are limited by their rapid degradation. One enzyme responsible for endocannabinoid breakdown is fatty acid amide hydrolase (FAAH). The present study examined whether URB597, a potent and selective FAAH inhibitor, could alter inflammation and pain in a mouse model of acute synovitis. |
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Canada | 7 | 50% |
Netherlands | 1 | 7% |
United Kingdom | 1 | 7% |
Unknown | 5 | 36% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 64% |
Scientists | 3 | 21% |
Practitioners (doctors, other healthcare professionals) | 2 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 3% |
Germany | 1 | 1% |
United States | 1 | 1% |
Unknown | 76 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 19 | 24% |
Student > Ph. D. Student | 14 | 18% |
Student > Master | 10 | 13% |
Researcher | 6 | 8% |
Other | 5 | 6% |
Other | 11 | 14% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 24% |
Agricultural and Biological Sciences | 8 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Neuroscience | 5 | 6% |
Other | 15 | 19% |
Unknown | 21 | 26% |