↓ Skip to main content

Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis

Overview of attention for article published in Diagnostic Pathology, September 2014
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

1 tweeter
1 Wikipedia page


41 Dimensions

Readers on

44 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis
Published in
Diagnostic Pathology, September 2014
DOI 10.1186/s13000-014-0167-y
Pubmed ID

Chong Xu, Yan Wu, Guodong Liu, Xiaoqiang Liu, Fang Wang, Jing Yu


BackgroundThe relationship between homocysteine (Hcy) and diabetic retinopathy (DR) remains unclear to date. Therefore, a systematic review and meta-analysis was performed on the relationship between Hcy level and DR.MethodsStudies were identified by searching PubMed, Embase, and Web of Science databases until 5 May, 2014.ResultsA total of 31 studies involving 6,394 participants were included in the meta-analysis. After pooling the data from each included study, the blood Hcy concentration in the DR group was observed to be higher than that in the control group [WMD¿=¿2.55; 95% confidence interval (CI), 1.70¿3.40], and diabetes mellitus (DM) patients with hyperhomocysteinemia were at a risk for DR [odds ratio (OR)¿=¿1.93; 95% CI, 1.46¿2.53]. Considering the different DM types, hyperhomocysteinemia in T1DM (OR¿=¿1.83, 95% CI, 1.28¿2.62) was associated with DR rather than in T2DM (OR¿=¿1.59, 95% CI, 0.72¿3.51). Considerable statistical heterogeneity in the overall summary estimates was partly explained by the geographical differences.ConclusionsResults from this current meta-analysis indicate that hyperhomocysteinemia is a risk factor for DR, especially proliferative DR. Differences between geographical regions were observed in the relationship between hyperhomocysteinemia with T1DM risk. Given the heterogeneous results, the relationship between high Hcy and DR needs further investigation.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_167.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 16%
Student > Ph. D. Student 6 14%
Other 5 11%
Student > Doctoral Student 4 9%
Student > Bachelor 4 9%
Other 10 23%
Unknown 8 18%
Readers by discipline Count As %
Medicine and Dentistry 23 52%
Unspecified 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Agricultural and Biological Sciences 2 5%
Nursing and Health Professions 1 2%
Other 5 11%
Unknown 8 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2015.
All research outputs
of 18,382,898 outputs
Outputs from Diagnostic Pathology
of 985 outputs
Outputs of similar age
of 219,457 outputs
Outputs of similar age from Diagnostic Pathology
of 1 outputs
Altmetric has tracked 18,382,898 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 985 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,457 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them