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Preconditioning of bone marrow mesenchymal stem cells by prolyl hydroxylase inhibition enhances cell survival and angiogenesis in vitro and after transplantation into the ischemic heart of rats

Overview of attention for article published in Stem Cell Research & Therapy, September 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 378)
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

dimensions_citation
73 Dimensions

Readers on

mendeley
66 Mendeley
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Title
Preconditioning of bone marrow mesenchymal stem cells by prolyl hydroxylase inhibition enhances cell survival and angiogenesis in vitro and after transplantation into the ischemic heart of rats
Published in
Stem Cell Research & Therapy, September 2014
DOI 10.1186/scrt499
Pubmed ID
Authors

Xian-Bao Liu, Jian-An Wang, Xiao-Ya Ji, Shan Ping Yu, Ling Wei

Abstract

Poor cell survival and limited functional benefits have restricted the efficacy of bone marrow mesenchymal stem cells (BMSCs) in the treatment of myocardial infarction. We showed recently that hypoxia preconditioning of BMSCs and neural progenitor cells before transplantation can enhance the survival and therapeutic properties of these cells in the ischemic brain and heart. The present investigation explores a novel strategy of preconditioning BMSCs using the Hypoxia-inducible factor 1alpha (HIF-alpha) prolyl hydroxylase inhibitor dimethyloxalylglycine (DMOG) to enhance their survival and therapeutic efficacy after transplantation into infarcted myocardium.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 24%
Student > Bachelor 10 15%
Researcher 7 11%
Student > Master 7 11%
Other 5 8%
Other 12 18%
Unknown 9 14%
Readers by discipline Count As %
Medicine and Dentistry 20 30%
Agricultural and Biological Sciences 11 17%
Biochemistry, Genetics and Molecular Biology 9 14%
Engineering 4 6%
Neuroscience 2 3%
Other 6 9%
Unknown 14 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2014.
All research outputs
#367,355
of 4,691,823 outputs
Outputs from Stem Cell Research & Therapy
#21
of 378 outputs
Outputs of similar age
#14,162
of 122,095 outputs
Outputs of similar age from Stem Cell Research & Therapy
#3
of 19 outputs
Altmetric has tracked 4,691,823 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 378 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,095 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.