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Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis

Overview of attention for article published in Orphanet Journal of Rare Diseases, September 2014
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Title
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis
Published in
Orphanet Journal of Rare Diseases, September 2014
DOI 10.1186/s13023-014-0148-y
Pubmed ID
Authors

Sigrun Eick, Magdalena Puklo, Karina Adamowicz, Tomasz Kantyka, Pieter Hiemstra, Henning Stennicke, Arndt Guentsch, Beate Schacher, Peter Eickholz, Jan Potempa

Abstract

Loss-of-function point mutations in the cathepsin C gene are the underlying genetic event in patients with Papillon-Lefèvre syndrome (PLS). PLS neutrophils lack serine protease activity essential for cathelicidin LL-37 generation from hCAP18 precursor.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 26%
Student > Bachelor 5 11%
Researcher 4 9%
Professor > Associate Professor 4 9%
Student > Master 4 9%
Other 9 20%
Unknown 8 17%
Readers by discipline Count As %
Medicine and Dentistry 21 46%
Agricultural and Biological Sciences 6 13%
Biochemistry, Genetics and Molecular Biology 5 11%
Immunology and Microbiology 1 2%
Business, Management and Accounting 1 2%
Other 2 4%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2014.
All research outputs
#17,727,479
of 22,764,165 outputs
Outputs from Orphanet Journal of Rare Diseases
#2,003
of 2,611 outputs
Outputs of similar age
#170,003
of 252,544 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#38
of 45 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,611 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,544 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.