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Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis

Overview of attention for article published in Orphanet Journal of Rare Diseases, September 2014
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2 tweeters

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Title
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis
Published in
Orphanet Journal of Rare Diseases, September 2014
DOI 10.1186/s13023-014-0148-y
Pubmed ID
Authors

Sigrun Eick, Magdalena Puklo, Karina Adamowicz, Tomasz Kantyka, Pieter Hiemstra, Henning Stennicke, Arndt Guentsch, Beate Schacher, Peter Eickholz, Jan Potempa

Abstract

Loss-of-function point mutations in the cathepsin C gene are the underlying genetic event in patients with Papillon-Lefèvre syndrome (PLS). PLS neutrophils lack serine protease activity essential for cathelicidin LL-37 generation from hCAP18 precursor.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 27%
Student > Bachelor 5 12%
Researcher 4 10%
Professor > Associate Professor 4 10%
Student > Master 4 10%
Other 9 22%
Unknown 4 10%
Readers by discipline Count As %
Medicine and Dentistry 21 51%
Agricultural and Biological Sciences 6 15%
Biochemistry, Genetics and Molecular Biology 4 10%
Immunology and Microbiology 1 2%
Business, Management and Accounting 1 2%
Other 2 5%
Unknown 6 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2014.
All research outputs
#3,201,365
of 4,304,920 outputs
Outputs from Orphanet Journal of Rare Diseases
#679
of 750 outputs
Outputs of similar age
#84,244
of 115,525 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#46
of 50 outputs
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So far Altmetric has tracked 750 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.