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Inhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4

Overview of attention for article published in BMC Microbiology, September 2014
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Title
Inhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4
Published in
BMC Microbiology, September 2014
DOI 10.1186/s12866-014-0237-z
Pubmed ID
Authors

Sehee Park, Jin Il Kim, Ilseob Lee, Joon-Yong Bae, Min-Woong Hwang, Donghwan Kim, Seok-Il Jang, Hyejin Kim, Mee Sook Park, Hyung-Joo Kwon, Jin-Won Song, Yong Suk Cho, Wook Chun, Man-Seong Park

Abstract

BackgroundHarassed with extensive epithelial burn wounds, patients can be affected by complications, such as infection, hypovolemic shock, hypothermia, and respiratory failure. Immediate first aid and followed supportive cares are critical for the prevention of severe complications. However, secondary bacterial infection is hard to be controlled in burn patients, and Pseudomonas aeruginosa (P. aeruginosa) is one of the top listed pathogens perturbing burn wounds beyond the antibiotics spectrum.ResultsTo find the way for efficacious protection from the pseudomonas-mediated complications in burn patients, we assessed the in vitro and in vivo inhibitory values of human ß-defensin 4 (hBD4), which is known as a member of the cationic, antimicrobial peptides found in human cells of many kinds. The Newcastle disease virus (NDV) was used as a viral vector for the expression of hBD4 in burn wounds. Expressed from the recombinant NDV (rNDV-hBD4), hBD4 effectively inhibited the pseudomonal growths in cell culture media. In a mouse model, severely burn-injured skin was recovered by the direct installation of the rNDV-hBD4 infected cells in the burn wounds whereas that of control mice remained severely damaged.ConclusionsWe suggest that the application of hBD4 may protect burn patients from secondary pseudomonal infection and provide a therapeutic potential for burn wound treatment.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 27%
Student > Master 3 14%
Student > Ph. D. Student 3 14%
Student > Doctoral Student 1 5%
Student > Bachelor 1 5%
Other 4 18%
Unknown 4 18%
Readers by discipline Count As %
Medicine and Dentistry 7 32%
Agricultural and Biological Sciences 5 23%
Biochemistry, Genetics and Molecular Biology 3 14%
Immunology and Microbiology 2 9%
Veterinary Science and Veterinary Medicine 1 5%
Other 0 0%
Unknown 4 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2014.
All research outputs
#15,306,466
of 22,764,165 outputs
Outputs from BMC Microbiology
#1,761
of 3,184 outputs
Outputs of similar age
#146,574
of 252,544 outputs
Outputs of similar age from BMC Microbiology
#12
of 40 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,184 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,544 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.