Title |
Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways
|
---|---|
Published in |
BMC Cancer, September 2014
|
DOI | 10.1186/1471-2407-14-729 |
Pubmed ID | |
Authors |
Jiumao Lin, Aling Shen, Hongwei Chen, Jun Liao, Teng Xu, Liya Liu, Jing Lin, Jun Peng |
Abstract |
The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might not always be therapeutically effective. Additionally, long-term use of these agents probably generates drug resistance and unacceptable adverse effects. These problems increase the necessity for the development of new chemotherapeutic approaches. Nitidine chloride (NC), a natural benzophenanthridine alkaloid, has been shown to inhibit cancer growth via induction of cell apoptosis and suppression of cancer angiogenesis. But the precise mechanisms of its tumorcidal activity are not well understood. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Members of the public | 1 | 33% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 23% |
Student > Ph. D. Student | 2 | 15% |
Lecturer > Senior Lecturer | 1 | 8% |
Researcher | 1 | 8% |
Student > Postgraduate | 1 | 8% |
Other | 0 | 0% |
Unknown | 5 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 23% |
Medicine and Dentistry | 2 | 15% |
Nursing and Health Professions | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Chemistry | 1 | 8% |
Other | 0 | 0% |
Unknown | 5 | 38% |