↓ Skip to main content

Oral vaccination of wildlife using a vaccinia–rabies-glycoprotein recombinant virus vaccine (RABORAL V-RG®): a global review

Overview of attention for article published in Veterinary Research, September 2017
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 1,188)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

news
5 news outlets
policy
1 policy source
twitter
14 tweeters
reddit
1 Redditor

Citations

dimensions_citation
93 Dimensions

Readers on

mendeley
181 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Oral vaccination of wildlife using a vaccinia–rabies-glycoprotein recombinant virus vaccine (RABORAL V-RG®): a global review
Published in
Veterinary Research, September 2017
DOI 10.1186/s13567-017-0459-9
Pubmed ID
Authors

Joanne Maki, Anne-Laure Guiot, Michel Aubert, Bernard Brochier, Florence Cliquet, Cathleen A. Hanlon, Roni King, Ernest H. Oertli, Charles E. Rupprecht, Caroline Schumacher, Dennis Slate, Boris Yakobson, Anne Wohlers, Emily W. Lankau

Abstract

RABORAL V-RG(®) is an oral rabies vaccine bait that contains an attenuated ("modified-live") recombinant vaccinia virus vector vaccine expressing the rabies virus glycoprotein gene (V-RG). Approximately 250 million doses have been distributed globally since 1987 without any reports of adverse reactions in wildlife or domestic animals since the first licensed recombinant oral rabies vaccine (ORV) was released into the environment to immunize wildlife populations against rabies. V-RG is genetically stable, is not detected in the oral cavity beyond 48 h after ingestion, is not shed by vaccinates into the environment, and has been tested for thermostability under a range of laboratory and field conditions. Safety of V-RG has been evaluated in over 50 vertebrate species, including non-human primates, with no adverse effects observed regardless of route or dose. Immunogenicity and efficacy have been demonstrated under laboratory and field conditions in multiple target species (including fox, raccoon, coyote, skunk, raccoon dog, and jackal). The liquid vaccine is packaged inside edible baits (i.e., RABORAL V-RG, the vaccine-bait product) which are distributed into wildlife habitats for consumption by target species. Field application of RABORAL V-RG has contributed to the elimination of wildlife rabies from three European countries (Belgium, France and Luxembourg) and of the dog/coyote rabies virus variant from the United States of America (USA). An oral rabies vaccination program in west-central Texas has essentially eliminated the gray fox rabies virus variant from Texas with the last case reported in a cow during 2009. A long-term ORV barrier program in the USA using RABORAL V-RG is preventing substantial geographic expansion of the raccoon rabies virus variant. RABORAL V-RG has also been used to control wildlife rabies in Israel for more than a decade. This paper: (1) reviews the development and historical use of RABORAL V-RG; (2) highlights wildlife rabies control programs using the vaccine in multiple species and countries; and (3) discusses current and future challenges faced by programs seeking to control or eliminate wildlife rabies.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 181 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 17%
Student > Bachelor 29 16%
Student > Master 28 15%
Student > Ph. D. Student 19 10%
Other 17 9%
Other 16 9%
Unknown 41 23%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 33 18%
Agricultural and Biological Sciences 28 15%
Biochemistry, Genetics and Molecular Biology 27 15%
Immunology and Microbiology 16 9%
Environmental Science 12 7%
Other 19 10%
Unknown 46 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2022.
All research outputs
#617,692
of 22,510,372 outputs
Outputs from Veterinary Research
#13
of 1,188 outputs
Outputs of similar age
#13,819
of 297,847 outputs
Outputs of similar age from Veterinary Research
#1
of 2 outputs
Altmetric has tracked 22,510,372 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,188 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,847 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them