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DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway

Overview of attention for article published in Cell Communication and Signaling, October 2017
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  • Good Attention Score compared to outputs of the same age (65th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

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2 X users
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1 Wikipedia page

Citations

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71 Dimensions

Readers on

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98 Mendeley
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Title
DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
Published in
Cell Communication and Signaling, October 2017
DOI 10.1186/s12964-017-0195-9
Pubmed ID
Authors

Sonali Bhattacharjee, Saikat Nandi

Abstract

Fanconi Anemia (FA) is a rare, inherited genomic instability disorder, caused by mutations in genes involved in the repair of interstrand DNA crosslinks (ICLs). The FA signaling network contains a unique nuclear protein complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. FA proteins act at different steps of ICL repair in sensing, recognition and processing of DNA lesions. The multi-protein network is tightly regulated by complex mechanisms, such as ubiquitination, phosphorylation, and degradation signals that are critical for the maintenance of genome integrity and suppressing tumorigenesis. Here, we discuss recent advances in our understanding of how the FA proteins participate in ICL repair and regulation of the FA signaling network that assures the safeguard of the genome. We further discuss the potential application of designing small molecule inhibitors that inhibit the FA pathway and are synthetic lethal with DNA repair enzymes that can be used for cancer therapeutics.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 98 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 26%
Researcher 13 13%
Student > Bachelor 10 10%
Student > Master 8 8%
Professor > Associate Professor 5 5%
Other 12 12%
Unknown 25 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 43 44%
Agricultural and Biological Sciences 9 9%
Medicine and Dentistry 7 7%
Immunology and Microbiology 3 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 7 7%
Unknown 27 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2023.
All research outputs
#7,274,223
of 25,200,621 outputs
Outputs from Cell Communication and Signaling
#217
of 1,414 outputs
Outputs of similar age
#109,517
of 330,471 outputs
Outputs of similar age from Cell Communication and Signaling
#3
of 13 outputs
Altmetric has tracked 25,200,621 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,414 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,471 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.