↓ Skip to main content

Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan

Overview of attention for article published in Trials, October 2014
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
72 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan
Published in
Trials, October 2014
DOI 10.1186/1745-6215-15-382
Pubmed ID
Authors

Willeke F Westendorp, Jan-Dirk Vermeij, Diederik W J Dippel, Marcel G W Dijkgraaf, Tom van der Poll, Jan M Prins, Frederique H Vermeij, Yvo B W E M Roos, Matthijs C Brouwer, Aeilko H Zwinderman, Diederik van de Beek, Paul J Nederkoorn

Abstract

Infections occur in 30% of stroke patients and are associated with unfavorable outcomes. Preventive antibiotic therapy lowers the infection rate after stroke, but the effect of preventive antibiotic treatment on functional outcome in patients with stroke is unknown. The PASS is a multicenter, prospective, phase three, randomized, open-label, blinded end-point (PROBE) trial of preventive antibiotic therapy in acute stroke. Patients are randomly assigned to either ceftriaxone at a dose of 2 g, given every 24 h intravenously for 4 days, in addition to standard stroke-unit care, or standard stroke-unit care without preventive antibiotic therapy. The aim of this study is to assess whether preventive antibiotic treatment improves functional outcome at 3 months by preventing infections. This paper presents in detail the statistical analysis plan (SAP) of the Preventive Antibiotics in Stroke Study (PASS) and was submitted while the investigators were still blinded for all outcomes.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 19%
Student > Master 8 11%
Student > Ph. D. Student 6 8%
Student > Bachelor 6 8%
Student > Doctoral Student 5 7%
Other 10 14%
Unknown 23 32%
Readers by discipline Count As %
Medicine and Dentistry 24 33%
Nursing and Health Professions 4 6%
Neuroscience 4 6%
Economics, Econometrics and Finance 4 6%
Mathematics 3 4%
Other 5 7%
Unknown 28 39%