Title |
Updates on cardiovascular outcome trials in diabetes
|
---|---|
Published in |
Cardiovascular Diabetology, October 2017
|
DOI | 10.1186/s12933-017-0610-y |
Pubmed ID | |
Authors |
Oliver Schnell, Lars Rydén, Eberhard Standl, Antonio Ceriello, on behalf of the D&CVD EASD Study Group |
Abstract |
In 2008 the Food and Drug Administration introduced a guidance for industry that requires the investigation of cardiovascular outcomes of glucose-lowering medications. Since then, an increasing number of cardiovascular outcome trials have been completed in diabetes patients with high cardiovascular risk for members of the SGLT-2 and DPP4 inhibitors and GLP-1 receptor agonist classes. The trials confirmed cardiovascular safety for all tested anti-hyperglycaemic drugs and, in addition empagliflozin, semaglutide and liraglutide could even reduce cardiovascular risk. The present review summarizes the results of the DEVOTE, CANVAS, EXSCEL and ACE trials that tested cardiovascular safety of Insulin degludec, canagliflozin, once-weekly exenatide and acarbose and were published in 2017. We provide context on these results by comparing them with earlier trials of glucose-lowering drugs and give an outlook on what to expect in coming years. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 25% |
Japan | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 120 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 20 | 17% |
Student > Master | 18 | 15% |
Student > Bachelor | 12 | 10% |
Other | 11 | 9% |
Student > Ph. D. Student | 9 | 8% |
Other | 22 | 18% |
Unknown | 28 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 55 | 46% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
Nursing and Health Professions | 6 | 5% |
Biochemistry, Genetics and Molecular Biology | 5 | 4% |
Agricultural and Biological Sciences | 2 | 2% |
Other | 9 | 8% |
Unknown | 35 | 29% |