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The gap between calculated and actual calcium substitution during citrate anticoagulation in an immobilised patient on renal replacement therapy reflects the extent of bone loss – a case report

Overview of attention for article published in BMC Nephrology, October 2014
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Title
The gap between calculated and actual calcium substitution during citrate anticoagulation in an immobilised patient on renal replacement therapy reflects the extent of bone loss – a case report
Published in
BMC Nephrology, October 2014
DOI 10.1186/1471-2369-15-163
Pubmed ID
Authors

Matthias Klingele, Sarah Seiler, Aaron Poppleton, Philip Lepper, Danilo Fliser, Roland Seidel

Abstract

Demineralisation and bone density loss during immobilisation are known phenomena. However information concerning the extent of calcium loss during immobilisation remains inconsistent within literature. This may explain why treatment of bone loss and prevention of further demineralisation is often initiated only when spontaneous bone fracture occurred.Continuous renal replacement therapy is commonly utilised in critically ill patients with acute kidney injury requiring RRT. Regional anticoagulation with citrate for CRRT is well-established within the intensive care setting. Due to calcium free dialysate, calcium is eliminated directly as well as indirectly via citrate binding necessitating calcium substitution. In anuric patients declining calcium requirements over time reflect bone calcium liberation secondary to immobilisation. The difference between the expected and actual need for calcium infusion corresponds to calcium release from bone which is particularly impressive in patients exposed to long-term immobilisation and CRRT. We report a dialysis period in excess of 250 days with continuous renal replacement therapy and anticoagulation with citrate.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Canada 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 24%
Other 6 13%
Student > Bachelor 4 9%
Researcher 4 9%
Student > Ph. D. Student 4 9%
Other 7 15%
Unknown 10 22%
Readers by discipline Count As %
Medicine and Dentistry 25 54%
Nursing and Health Professions 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Sports and Recreations 2 4%
Psychology 1 2%
Other 1 2%
Unknown 12 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2014.
All research outputs
#17,728,060
of 22,765,347 outputs
Outputs from BMC Nephrology
#1,699
of 2,463 outputs
Outputs of similar age
#171,075
of 254,034 outputs
Outputs of similar age from BMC Nephrology
#31
of 47 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,463 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.