Title |
Genome sequencing and genomic characterization of a tigecycline-resistant Klebsiella pneumoniae strain isolated from the bile samples of a cholangiocarcinoma patient
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Published in |
Gut Pathogens, September 2014
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DOI | 10.1186/s13099-014-0040-2 |
Pubmed ID | |
Authors |
Beiwen Zheng, Ang Li, Xiawei Jiang, Xinjun Hu, Jian Yao, Lina Zhao, Jinru Ji, Min Ye, Yonghong Xiao, Lanjuan Li |
Abstract |
The relationship between Klebsiella pneumoniae and nosocomial and community-acquired infections is well known, and K. pneumoniae resistance to most antibiotics is increasing worldwide. In contrast, tigecycline remains active against many bacterial strains, and serves as a last resort for treating multi-drug resistant bacterial infections. That tigecycline nonsusceptibility among K. pneumoniae isolates has been reported worldwide is worrying. However, the mechanisms of tigecycline resistance in K. pneumoniae are less well known. We report the genome sequence and genomic characterization of tigecycline-resistant K. pneumoniae strain 5422 isolated from the bile samples of a patient with cholangiocarcinoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Ireland | 1 | 2% |
Unknown | 47 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 18% |
Student > Bachelor | 6 | 12% |
Student > Master | 5 | 10% |
Student > Ph. D. Student | 4 | 8% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 14% |
Unknown | 16 | 33% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 20% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Immunology and Microbiology | 6 | 12% |
Medicine and Dentistry | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 2 | 4% |
Unknown | 17 | 35% |