Title |
Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease
|
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Published in |
BMC Genomics, October 2014
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DOI | 10.1186/1471-2164-15-850 |
Pubmed ID | |
Authors |
David G Ashbrook, Robert W Williams, Lu Lu, Jason L Stein, Derrek P Hibar, Thomas E Nichols, Sarah E Medland, Paul M Thompson, Reinmar Hager |
Abstract |
Variation in hippocampal volume has been linked to significant differences in memory, behavior, and cognition among individuals. To identify genetic variants underlying such differences and associated disease phenotypes, multinational consortia such as ENIGMA have used large magnetic resonance imaging (MRI) data sets in human GWAS studies. In addition, mapping studies in mouse model systems have identified genetic variants for brain structure variation with great power. A key challenge is to understand how genetically based differences in brain structure lead to the propensity to develop specific neurological disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 21% |
Canada | 1 | 7% |
France | 1 | 7% |
Unknown | 9 | 64% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 11 | 79% |
Scientists | 2 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Taiwan | 1 | 2% |
Unknown | 60 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 19% |
Researcher | 8 | 13% |
Student > Bachelor | 7 | 11% |
Other | 5 | 8% |
Student > Master | 5 | 8% |
Other | 11 | 18% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 23% |
Agricultural and Biological Sciences | 9 | 15% |
Neuroscience | 6 | 10% |
Medicine and Dentistry | 4 | 6% |
Psychology | 4 | 6% |
Other | 10 | 16% |
Unknown | 15 | 24% |