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Nanotechnology-based drug delivery systems

Overview of attention for article published in Journal of Occupational Medicine and Toxicology, January 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

policy
1 policy source
patent
1 patent
facebook
2 Facebook pages

Citations

dimensions_citation
348 Dimensions

Readers on

mendeley
558 Mendeley
citeulike
1 CiteULike
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Title
Nanotechnology-based drug delivery systems
Published in
Journal of Occupational Medicine and Toxicology, January 2007
DOI 10.1186/1745-6673-2-16
Pubmed ID
Authors

Sarabjeet Suri, Hicham Fenniri, Baljit Singh

Abstract

Nanoparticles hold tremendous potential as an effective drug delivery system. In this review we discussed recent developments in nanotechnology for drug delivery. To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. To achieve efficient drug delivery it is important to understand the interactions of nanomaterials with the biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents and molecular mechanisms of cell signalling involved in pathobiology of the disease under consideration. Several anti-cancer drugs including paclitaxel, doxorubicin, 5-fluorouracil and dexamethasone have been successfully formulated using nanomaterials. Quantom dots, chitosan, Polylactic/glycolic acid (PLGA) and PLGA-based nanoparticles have also been used for in vitro RNAi delivery. Brain cancer is one of the most difficult malignancies to detect and treat mainly because of the difficulty in getting imaging and therapeutic agents past the blood-brain barrier and into the brain. Anti-cancer drugs such as loperamide and doxorubicin bound to nanomaterials have been shown to cross the intact blood-brain barrier and released at therapeutic concentrations in the brain. The use of nanomaterials including peptide-based nanotubes to target the vascular endothelial growth factor (VEGF) receptor and cell adhesion molecules like integrins, cadherins and selectins, is a new approach to control disease progression.

Mendeley readers

The data shown below were compiled from readership statistics for 558 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 4 <1%
United States 2 <1%
Sri Lanka 2 <1%
Iran, Islamic Republic of 2 <1%
Egypt 2 <1%
United Kingdom 1 <1%
Russia 1 <1%
Indonesia 1 <1%
Unknown 543 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 123 22%
Student > Ph. D. Student 116 21%
Student > Bachelor 104 19%
Researcher 45 8%
Student > Postgraduate 25 4%
Other 72 13%
Unknown 73 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 85 15%
Chemistry 84 15%
Pharmacology, Toxicology and Pharmaceutical Science 83 15%
Biochemistry, Genetics and Molecular Biology 55 10%
Medicine and Dentistry 42 8%
Other 103 18%
Unknown 106 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2019.
All research outputs
#3,349,091
of 17,353,889 outputs
Outputs from Journal of Occupational Medicine and Toxicology
#53
of 342 outputs
Outputs of similar age
#42,032
of 218,097 outputs
Outputs of similar age from Journal of Occupational Medicine and Toxicology
#1
of 1 outputs
Altmetric has tracked 17,353,889 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 342 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 218,097 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them