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Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?

Overview of attention for article published in Cancer & Metabolism, October 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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3 X users
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1 patent
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1 Facebook page

Citations

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58 Dimensions

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100 Mendeley
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Title
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
Published in
Cancer & Metabolism, October 2014
DOI 10.1186/2049-3002-2-16
Pubmed ID
Authors

Rana Elkholi, Thibaud T Renault, Madhavika N Serasinghe, Jerry E Chipuk

Abstract

In order to solve a jigsaw puzzle, one must first have the complete picture to logically connect the pieces. However, in cancer biology, we are still gaining an understanding of all the signaling pathways that promote tumorigenesis and how these pathways can be pharmacologically manipulated by conventional and targeted therapies. Despite not having complete knowledge of the mechanisms that cause cancer, the signaling networks responsible for cancer are becoming clearer, and this information is serving as a solid foundation for the development of rationally designed therapies. One goal of chemotherapy is to induce cancer cell death through the mitochondrial pathway of apoptosis. Within this review, we present the pathways that govern the cellular decision to undergo apoptosis as three distinct, yet connected puzzle pieces: (1) How do oncogene and tumor suppressor pathways regulate apoptosis upstream of mitochondria? (2) How does the B-cell lymphoma 2 (BCL-2) family influence tumorigenesis and chemotherapeutic responses? (3) How is post-mitochondrial outer membrane permeabilization (MOMP) regulation of cell death relevant in cancer? When these pieces are united, it is possible to appreciate how cancer signaling directly impacts upon the fundamental cellular mechanisms of apoptosis and potentially reveals novel pharmacological targets within these pathways that may enhance chemotherapeutic success.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Spain 1 1%
Kenya 1 1%
Unknown 96 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 25%
Student > Master 17 17%
Researcher 11 11%
Student > Bachelor 9 9%
Lecturer 4 4%
Other 12 12%
Unknown 22 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 28%
Agricultural and Biological Sciences 23 23%
Chemistry 7 7%
Medicine and Dentistry 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 9 9%
Unknown 25 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2021.
All research outputs
#6,603,068
of 23,758,334 outputs
Outputs from Cancer & Metabolism
#73
of 210 outputs
Outputs of similar age
#68,616
of 256,166 outputs
Outputs of similar age from Cancer & Metabolism
#4
of 7 outputs
Altmetric has tracked 23,758,334 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 210 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.