Title |
Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix
|
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Published in |
BMC Cancer, October 2014
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DOI | 10.1186/1471-2407-14-751 |
Pubmed ID | |
Authors |
Céline Pinheiro, Eduardo A Garcia, Filipa Morais-Santos, Cristovam Scapulatempo-Neto, Allini Mafra, Renske DM Steenbergen, Enrique Boccardo, Luisa L Villa, Fátima Baltazar, Adhemar Longatto-Filho |
Abstract |
Tumour microenvironment is a fundamental aspect of tumour behaviour, modulating important events as cancer cell migration and invasion, as well as angiogenesis and metastisation. Among other microenvironment features, hypoxia and acidity play important roles in this modulation. As the metabolic reprogramming of cancer cells induces extracellular acidity, which in turn induces angiogenesis, and hypoxia induces both the metabolic reprogramming and angiogenesis, the present study aims to evaluate the immunohistochemical expression of a variety of metabolic and vascular markers as common targets of the hypoxic microenvironment in a series of cervical squamous cells carcinoma, as well as using an in vitro 3D culture model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 18% |
Student > Master | 8 | 16% |
Student > Doctoral Student | 5 | 10% |
Researcher | 5 | 10% |
Student > Ph. D. Student | 4 | 8% |
Other | 8 | 16% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 27% |
Biochemistry, Genetics and Molecular Biology | 10 | 20% |
Agricultural and Biological Sciences | 4 | 8% |
Social Sciences | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 4 | 8% |
Unknown | 15 | 29% |