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Good guy or bad guy: the opposing roles of microRNA 125b in cancer

Overview of attention for article published in Cell Communication and Signaling, April 2014
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
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1 patent

Citations

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146 Dimensions

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120 Mendeley
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Title
Good guy or bad guy: the opposing roles of microRNA 125b in cancer
Published in
Cell Communication and Signaling, April 2014
DOI 10.1186/1478-811x-12-30
Pubmed ID
Authors

Julia Banzhaf-Strathmann, Dieter Edbauer

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally silence target mRNAs. Dysregulation of miRNAs is a frequent event in several diseases, including cancer. One miRNA that has gained special interest in the field of cancer research is miRNA-125b (miR-125b). MiR-125b is a ubiquitously expressed miRNA that is aberrantly expressed in a great variety of tumors. In some tumor types, e.g. colon cancer and hematopoietic tumors, miR-125b is upregulated and displays oncogenic potential, as it induces cell growth and proliferation, while blocking the apoptotic machinery. In contrast, in other tumor entities, e.g. mammary tumors and hepatocellular carcinoma, miR-125b is heavily downregulated. This downregulation is accompanied by de-repression of cellular proliferation and anti-apoptotic programs, contributing to malignant transformation. The reasons for these opposing roles are poorly understood. We summarize the current knowledge of miR-125b and its relevant targets in different tumor types and offer several hypotheses for the opposing roles of miR-125b: miR-125b targets multiple mRNAs, which have diverse functions in individual tissues. These target mRNAs are tissue and tumor specifically expressed, suggesting that misregulation by miR-125b depends on the levels of target gene expression. Moreover, we provide several examples that miR-125b upregulation dictates oncogenic characteristics, while downregulation of miR-125b corresponds to the loss of tumor suppressive functions. Thus, in different tumor entities increased or decreased miR-125b expression may contribute to carcinogenesis.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Namibia 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 116 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 26%
Researcher 19 16%
Student > Master 17 14%
Student > Bachelor 14 12%
Student > Doctoral Student 6 5%
Other 11 9%
Unknown 22 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 29%
Biochemistry, Genetics and Molecular Biology 31 26%
Medicine and Dentistry 17 14%
Immunology and Microbiology 3 3%
Business, Management and Accounting 2 2%
Other 7 6%
Unknown 25 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2021.
All research outputs
#7,355,485
of 25,371,288 outputs
Outputs from Cell Communication and Signaling
#230
of 1,499 outputs
Outputs of similar age
#66,814
of 242,060 outputs
Outputs of similar age from Cell Communication and Signaling
#6
of 10 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,499 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,060 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.