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Microglial pathology

Overview of attention for article published in Acta Neuropathologica Communications, September 2014
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Average Attention Score compared to outputs of the same age and source

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Citations

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333 Mendeley
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Title
Microglial pathology
Published in
Acta Neuropathologica Communications, September 2014
DOI 10.1186/s40478-014-0142-6
Pubmed ID
Authors

Wolfgang J Streit, Qing-Shan Xue, Jasmin Tischer, Ingo Bechmann

Abstract

This paper summarizes pathological changes that affect microglial cells in the human brain during aging and in aging-related neurodegenerative diseases, primarily Alzheimer¿s disease (AD). It also provides examples of microglial changes that have been observed in laboratory animals during aging and in some experimentally induced lesions and disease models. Dissimilarities and similarities between humans and rodents are discussed in an attempt to generate a current understanding of microglial pathology and its significance during aging and in the pathogenesis of Alzheimer dementia (AD). The identification of dystrophic (senescent) microglia has created an ostensible conflict with prior work claiming a role for activated microglia and neuroinflammation during normal aging and in AD, and this has raised a basic question: does the brain¿s immune system become hyperactive (inflamed) or does it become weakened (senescent) in elderly and demented people, and what is the impact on neuronal function and cognition? Here we strive to reconcile these seemingly contradictory notions by arguing that both low-grade neuroinflammation and microglial senescence are the result of aging-associated free radical injury. Both processes are damaging for microglia as they synergistically exhaust this essential cell population to the point where the brain¿s immune system is effete and unable to support neuronal function.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 <1%
United States 2 <1%
China 1 <1%
France 1 <1%
Japan 1 <1%
Luxembourg 1 <1%
Unknown 324 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 63 19%
Student > Ph. D. Student 62 19%
Student > Bachelor 46 14%
Student > Master 45 14%
Student > Doctoral Student 13 4%
Other 45 14%
Unknown 59 18%
Readers by discipline Count As %
Neuroscience 82 25%
Agricultural and Biological Sciences 53 16%
Biochemistry, Genetics and Molecular Biology 38 11%
Medicine and Dentistry 38 11%
Immunology and Microbiology 13 4%
Other 39 12%
Unknown 70 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2018.
All research outputs
#7,202,561
of 22,766,595 outputs
Outputs from Acta Neuropathologica Communications
#940
of 1,371 outputs
Outputs of similar age
#77,834
of 252,273 outputs
Outputs of similar age from Acta Neuropathologica Communications
#9
of 16 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,371 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.