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Mendeley readers
Attention Score in Context
| Title |
5-HT6 receptors and Alzheimer's disease
|
|---|---|
| Published in |
Alzheimer's Research & Therapy, April 2013
|
| DOI | 10.1186/alzrt169 |
| Pubmed ID | |
| Authors |
María Javier Ramírez |
| Abstract |
During the past 20 years, the 5-HT6 receptor has received increasing attention and become a promising target for improving cognition. Several studies with structurally different compounds have shown that not only antagonists but also 5-HT6 receptor agonists improve learning and memory in animal models. A large number of publications describing the development of ligands for this receptor have come to light, and it is now quite evident that 5-HT6 receptors have great pharmaceutical potential in terms of related patents. However, 5-HT6 receptor functionality is much more complex than initially defined. According to the existing data, different cellular pathways may be activated, depending on the drug being used. This article reviews preclinical and clinical evidence of the effects that 5-HT6 receptor compounds have on cognition. In addition, the biochemical and neurochemical mechanisms of action through which 5-HT6 receptor compounds can influence cognition will be described. Overall, several 5-HT6-targeted compounds can reasonably be regarded as powerful drug candidates for the treatment of Alzheimer's disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Unknown | 126 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 18% |
| Student > Bachelor | 22 | 17% |
| Student > Ph. D. Student | 19 | 15% |
| Researcher | 15 | 12% |
| Student > Doctoral Student | 6 | 5% |
| Other | 19 | 15% |
| Unknown | 23 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 20% |
| Chemistry | 23 | 18% |
| Neuroscience | 13 | 10% |
| Medicine and Dentistry | 13 | 10% |
| Agricultural and Biological Sciences | 10 | 8% |
| Other | 15 | 12% |
| Unknown | 27 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2017.
All research outputs
#904,735
of 22,766,595 outputs
Outputs from Alzheimer's Research & Therapy
#104
of 1,211 outputs
Outputs of similar age
#7,216
of 196,539 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#2
of 4 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,211 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,539 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.