Title |
Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma
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Published in |
Diabetology & Metabolic Syndrome, September 2014
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DOI | 10.1186/1758-5996-6-101 |
Pubmed ID | |
Authors |
Jing Wan, Zhichao Xiao, Shengping Chao, Shixi Xiong, Xuedong Gan, Xuguang Qiu, Chang Xu, Yexin Ma, Xin Tu |
Abstract |
PPARγ is a member of the nuclear hormone receptor superfamily. It has been considered as a mediator regulating metabolism, anti-inflammation, and pro-proliferation in the Vascular Smooth Muscle Cells (VSMCs). Thiazolidinediones (TZDs), synthetic ligands of PPARγ, have anti-proliferative and pro-apoptotic effects on VSMCs, which prevent the formation and progression of atherosclerosis and restenosis following percutaneous coronary intervention (PCI). However, the underlying mechanism remains elusive. This present study therefore aimed to investigate the signaling pathway by which pioglitazone, one of TZDs, inhibits proliferation and induces apoptosis of VSMCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 2 | 20% |
Student > Master | 2 | 20% |
Student > Bachelor | 2 | 20% |
Unspecified | 1 | 10% |
Student > Ph. D. Student | 1 | 10% |
Other | 1 | 10% |
Unknown | 1 | 10% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 30% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 20% |
Unspecified | 2 | 20% |
Energy | 1 | 10% |
Chemistry | 1 | 10% |
Other | 0 | 0% |
Unknown | 1 | 10% |