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Renal manifestations of HIV during the antiretroviral era in South Africa: a systematic scoping review

Overview of attention for article published in Systematic Reviews, October 2017
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Title
Renal manifestations of HIV during the antiretroviral era in South Africa: a systematic scoping review
Published in
Systematic Reviews, October 2017
DOI 10.1186/s13643-017-0605-5
Pubmed ID
Authors

Shirelle Assaram, Nombulelo P. Magula, Suman Mewa Kinoo, Tivani P. Mashamba-Thompson

Abstract

It is estimated that 650,000 patients may develop human immunodeficiency virus (HIV)-related renal disease in South Africa. South Africa has recently adopted WHO policy, stipulating that all HIV-infected patients have access to antiretroviral treatment (ART) irrespective of CD4 cell count. We searched Google Scholar, PubMed, Medline, Cochrane Library, Worldcat.org and EBSCO host databases from July 2015 to December 2015. Eligibility criteria included articles pertaining to renal manifestations of HIV in South Africa from 2004 to 2015 in adult patients (≥ 18 years). We independently reviewed the articles for quality. Thematic content analysis was performed to identify patterns of renal manifestations from the included studies. The risk of bias (e.g. internal validity) in the included studies was evaluated using the mixed methods appraisal tool. Eleven out 21 studies were eligible for data extraction. The prevalence of urine abnormalities on urine dipsticks was high but had poor sensitivity and specificity for detecting renal impairment. Normal renal function occurred in 28.4 to 79% of patients, mild renal impairment occurred in 19 to 57.1% and moderate renal impairment in 2 to 14.4%. Severe renal impairment occurred in 1.3% of patients. Both the Cockcroft-Gault equation (after correcting for bias) and the 4-variable Modification of Diet in Renal Disease equation (without the ethnicity factor for African Americans) have been validated for the estimation of glomerular filtration rate (eGFR) in Black South Africans. HIV-associated nephropathy was the most prevalent histology seen (57.2%). Older age, a lower CD4 count, a low haemoglobin and a detectable viral load were associated with renal impairment. Renal function improved in the first year of commencing ART as evidenced by the regression of proteinuria and the increase in eGFR. The findings of the review have implications to the recently adopted 'test and treat' approach to HIV prevention and management. PROSPERO CRD42016039270.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 20%
Student > Postgraduate 9 13%
Researcher 8 12%
Other 5 7%
Lecturer 4 6%
Other 12 17%
Unknown 17 25%
Readers by discipline Count As %
Medicine and Dentistry 26 38%
Nursing and Health Professions 10 14%
Biochemistry, Genetics and Molecular Biology 3 4%
Social Sciences 3 4%
Arts and Humanities 2 3%
Other 9 13%
Unknown 16 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2017.
All research outputs
#9,616,853
of 12,019,430 outputs
Outputs from Systematic Reviews
#790
of 906 outputs
Outputs of similar age
#206,511
of 284,002 outputs
Outputs of similar age from Systematic Reviews
#66
of 90 outputs
Altmetric has tracked 12,019,430 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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