Title |
Regulation of lncRNA expression
|
---|---|
Published in |
Cellular & Molecular Biology Letters, October 2014
|
DOI | 10.2478/s11658-014-0212-6 |
Pubmed ID | |
Authors |
Zhuomin Wu, Xiaoxia Liu, Li Liu, Houliang Deng, Jingjing Zhang, Qian Xu, Bohong Cen, Aimin Ji |
Abstract |
Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 155 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 19% |
Student > Master | 29 | 19% |
Researcher | 22 | 14% |
Student > Bachelor | 17 | 11% |
Student > Doctoral Student | 7 | 5% |
Other | 17 | 11% |
Unknown | 33 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 55 | 35% |
Agricultural and Biological Sciences | 28 | 18% |
Medicine and Dentistry | 11 | 7% |
Neuroscience | 4 | 3% |
Immunology and Microbiology | 3 | 2% |
Other | 16 | 10% |
Unknown | 38 | 25% |