Title |
Therapeutic effects of amniotic fluid-derived mesenchymal stromal cells on lung injury in rats with emphysema
|
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Published in |
Respiratory Research, October 2014
|
DOI | 10.1186/s12931-014-0120-3 |
Pubmed ID | |
Authors |
Yaqing Li, Chao Gu, Wulin Xu, Jianping Yan, Yingjie Xia, Yingyu Ma, Chun Chen, Xujun He, Houquan Tao |
Abstract |
In chronic obstructive pulmonary disease (COPD), two major pathological changes that occur are the loss of alveolar structure and airspace enlargement. To treat COPD, it is crucial to repair damaged lung tissue and regenerate the lost alveoli. Type II alveolar epithelial cells (AECII) play a vital role in maintaining lung tissue repair, and amniotic fluid-derived mesenchymal stromal cells (AFMSCs) possess the characteristics of regular mesenchymal stromal cells. However, it remains untested whether transplantation of rat AFMSCs (rAFMSCs) might alleviate lung injury caused by emphysema by increasing the expression of surfactant protein (SP)A and SPC and inhibiting AECII apoptosis. |
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