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Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells

Overview of attention for article published in BMC Cancer, October 2014
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3 X users

Citations

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31 Dimensions

Readers on

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24 Mendeley
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Title
Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells
Published in
BMC Cancer, October 2014
DOI 10.1186/1471-2407-14-768
Pubmed ID
Authors

Jing Wang, Song Gu, Jun Huang, Sheng Chen, Zhen Zhang, Min Xu

Abstract

Aberrant Hedgehog (Hh) signaling is often associated with neuroblastoma (NB), a childhood malignancy with varying clinical outcomes due to different molecular characteristics. Inhibition of Hh signaling with small molecule inhibitors, particularly with GANT-61, significantly suppresses NB growth. However, NB with MYCN amplification is less sensitive to GANT-61 than those without MYCN amplification.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 17%
Student > Doctoral Student 3 13%
Student > Master 3 13%
Student > Ph. D. Student 2 8%
Other 2 8%
Other 2 8%
Unknown 8 33%
Readers by discipline Count As %
Medicine and Dentistry 4 17%
Agricultural and Biological Sciences 4 17%
Biochemistry, Genetics and Molecular Biology 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Neuroscience 1 4%
Other 1 4%
Unknown 11 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2014.
All research outputs
#14,787,304
of 22,766,595 outputs
Outputs from BMC Cancer
#3,661
of 8,278 outputs
Outputs of similar age
#142,807
of 258,403 outputs
Outputs of similar age from BMC Cancer
#73
of 165 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,278 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,403 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.