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Galantamine Alleviates Inflammation and Other Obesity-Associated Complications in High-Fat Diet-Fed Mice

Overview of attention for article published in Molecular Medicine, July 2011
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

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2 patents

Citations

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94 Dimensions

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Title
Galantamine Alleviates Inflammation and Other Obesity-Associated Complications in High-Fat Diet-Fed Mice
Published in
Molecular Medicine, July 2011
DOI 10.2119/molmed.2011.00083
Pubmed ID
Authors

Sanjaya K Satapathy, Mahendar Ochani, Meghan Dancho, LaQueta K Hudson, Mauricio Rosas-Ballina, Sergio I Valdes-Ferrer, Peder S Olofsson, Yael Tobi Harris, Jesse Roth, Sangeeta Chavan, Kevin J Tracey, Valentin A Pavlov

Abstract

Obesity, a serious and growing health threat, is associated with low-grade inflammation that plays a role in mediating its adverse consequences. Previously, we have discovered a role for neural cholinergic signaling in controlling inflammation, and demonstrated that the cholinergic agent galantamine suppresses excessive proinflammatory cytokine release. The main objective of this study was to examine the efficacy of galantamine, a clinically-approved drug, in alleviating obesity-related inflammation and associated complications. After 8 wks on a high-fat diet, C57BL/6J mice were treated with either galantamine (4 mg/kg, intraperitoneally [i.p.]) or saline for 4 wks in parallel with mice on a low-fat diet and treated with saline. Galantamine treatment of obese mice significantly reduced body weight, food intake, abdominal adiposity, plasma cytokine and adipokine levels, and significantly improved blood glucose, insulin resistance and hepatic steatosis. In addition, galantamine alleviated impaired insulin sensitivity and glucose intolerance significantly. These results indicate a previously unrecognized potential of galantamine in alleviating obesity, inflammation and other obesity-related complications in mice. These findings are of interest for studying the efficacy of this clinically-approved drug in the context of human obesity and metabolic syndrome.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 17%
Student > Ph. D. Student 11 16%
Student > Bachelor 11 16%
Student > Master 6 9%
Professor 3 4%
Other 11 16%
Unknown 15 22%
Readers by discipline Count As %
Medicine and Dentistry 15 22%
Neuroscience 8 12%
Agricultural and Biological Sciences 8 12%
Pharmacology, Toxicology and Pharmaceutical Science 7 10%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 9 13%
Unknown 20 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2022.
All research outputs
#4,158,039
of 25,461,852 outputs
Outputs from Molecular Medicine
#180
of 1,207 outputs
Outputs of similar age
#21,251
of 127,305 outputs
Outputs of similar age from Molecular Medicine
#3
of 13 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,207 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,305 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.