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Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine

Overview of attention for article published in Nutrition & Metabolism, October 2017
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Title
Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine
Published in
Nutrition & Metabolism, October 2017
DOI 10.1186/s12986-017-0221-3
Pubmed ID
Authors

Octave Mucunguzi, Aicha Melouane, Abdelaziz Ghanemi, Mayumi Yoshioka, André Boivin, Ezequiel-Luis Calvo, Jonny St-Amand

Abstract

High-fat (HF) diet is a well-known cause of obesity. To identify principle transcriptional regulators that could be therapeutic targets of obesity, we investigated transcriptomic modulation in the duodenal mucosa following low-fat (LF) and HF meal ingestion. Whereas one group of mice was sacrificed after fasting, the others were fed ad libitum with LF or HF meal, and sacrificed 30 min, 1 h and 3 h after the beginning of the meal. A transcriptome analysis of the duodenal mucosa of the 7 groups was conducted using both microarray and serial analysis of gene expression (SAGE) method followed by an Ingenuity Pathways Analysis (IPA). SAGE and microarray showed that the modulation of a total of 896 transcripts in the duodenal mucosa after LF and/or HF meal, compared to the fasting condition. The IPA identified lipid metabolism, molecular transport, and small molecule biochemistry as top three molecular and cellular functions for the HF-responsive, HF-specific, HF-delay, and LF-HF different genes. Moreover, the top transcriptional regulator for the HF-responsive and HF-specific genes was peroxisome proliferator-activated receptor alpha (PPARα). On the other hand, the LF-responsive and LF-specific genes were related to carbohydrate metabolism, cellular function and maintenance, and cell death/cellular growth and proliferation, and the top transcriptional regulators were forkhead box protein O1 (FOXO1) and cAMP response element binding protein 1 (CREB1), respectively. These results will help to understand the molecular mechanisms of intestinal response after LF and HF ingestions, and contribute to identify therapeutic targets for obesity and obesity-related diseases.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 25%
Student > Bachelor 1 8%
Other 1 8%
Student > Master 1 8%
Researcher 1 8%
Other 0 0%
Unknown 5 42%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 25%
Mathematics 1 8%
Agricultural and Biological Sciences 1 8%
Economics, Econometrics and Finance 1 8%
Medicine and Dentistry 1 8%
Other 0 0%
Unknown 5 42%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2017.
All research outputs
#9,266,982
of 12,061,875 outputs
Outputs from Nutrition & Metabolism
#517
of 617 outputs
Outputs of similar age
#188,352
of 284,968 outputs
Outputs of similar age from Nutrition & Metabolism
#15
of 23 outputs
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.