↓ Skip to main content

Microphysiological systems and low-cost microfluidic platform with analytics

Overview of attention for article published in Stem Cell Research & Therapy, December 2013
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
89 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Microphysiological systems and low-cost microfluidic platform with analytics
Published in
Stem Cell Research & Therapy, December 2013
DOI 10.1186/scrt370
Pubmed ID
Authors

Alec ST Smith, Christopher J Long, Bonnie J Berry, Christopher McAleer, Maria Stancescu, Peter Molnar, Paula G Miller, Mandy B Esch, Jean-Matthieu Prot, James J Hickman, Michael L Shuler

Abstract

A multiorgan, functional, human in vitro assay system or 'Body-on-a-Chip' would be of tremendous benefit to the drug discovery and toxicology industries, as well as providing a more biologically accurate model for the study of disease as well as applied and basic biological research. Here, we describe the advances our team has made towards this goal, as well as the most pertinent issues facing further development of these systems. Description is given of individual organ models with appropriate cellular functionality, and our efforts to produce human iterations of each using primary and stem cell sources for eventual incorporation into this system. Advancement of the 'Body-on-a-Chip' field is predicated on the availability of abundant sources of human cells, capable of full differentiation and maturation to adult phenotypes, for which researchers are largely dependent on stem cells. Although this level of maturation is not yet achievable in all cell types, the work of our group highlights the high level of functionality that can be achieved using current technology, for a wide variety of cell types. As availability of functional human cell types for in vitro culture increases, the potential to produce a multiorgan in vitro system capable of accurately reproducing acute and chronic human responses to chemical and pathological challenge in real time will also increase.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 4%
Austria 1 1%
Germany 1 1%
United Kingdom 1 1%
Finland 1 1%
Unknown 81 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 26%
Researcher 13 15%
Student > Bachelor 11 12%
Student > Doctoral Student 8 9%
Student > Master 7 8%
Other 13 15%
Unknown 14 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 26%
Engineering 16 18%
Biochemistry, Genetics and Molecular Biology 10 11%
Medicine and Dentistry 9 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 12 13%
Unknown 15 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2014.
All research outputs
#12,838,902
of 19,432,554 outputs
Outputs from Stem Cell Research & Therapy
#1,069
of 1,990 outputs
Outputs of similar age
#140,103
of 247,656 outputs
Outputs of similar age from Stem Cell Research & Therapy
#34
of 43 outputs
Altmetric has tracked 19,432,554 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,990 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,656 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.