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The emerging roles of NGS-based liquid biopsy in non-small cell lung cancer

Overview of attention for article published in Journal of Hematology & Oncology, October 2017
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Title
The emerging roles of NGS-based liquid biopsy in non-small cell lung cancer
Published in
Journal of Hematology & Oncology, October 2017
DOI 10.1186/s13045-017-0536-6
Pubmed ID
Authors

Yi-Chen Zhang, Qing Zhou, Yi-Long Wu

Abstract

The treatment paradigm of non-small cell lung cancer (NSCLC) has evolved into oncogene-directed precision medicine. Identifying actionable genomic alterations is the initial step towards precision medicine. An important scientific progress in molecular profiling of NSCLC over the past decade is the shift from the traditional piecemeal fashion to massively parallel sequencing with the use of next-generation sequencing (NGS). Another technical advance is the development of liquid biopsy with great potential in providing a dynamic and comprehensive genomic profiling of NSCLC in a minimally invasive manner. The integration of NGS with liquid biopsy has been demonstrated to play emerging roles in genomic profiling of NSCLC by increasing evidences. This review summarized the potential applications of NGS-based liquid biopsy in the diagnosis and treatment of NSCLC including identifying actionable genomic alterations, tracking spatiotemporal tumor evolution, dynamically monitoring response and resistance to targeted therapies, and diagnostic value in early-stage NSCLC, and discussed emerging challenges to overcome in order to facilitate clinical translation in future.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 103 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 17%
Student > Ph. D. Student 14 14%
Student > Master 12 12%
Researcher 10 10%
Other 9 9%
Other 13 13%
Unknown 27 26%
Readers by discipline Count As %
Medicine and Dentistry 25 24%
Biochemistry, Genetics and Molecular Biology 23 22%
Agricultural and Biological Sciences 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Economics, Econometrics and Finance 3 3%
Other 11 11%
Unknown 32 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2021.
All research outputs
#18,574,814
of 23,006,268 outputs
Outputs from Journal of Hematology & Oncology
#931
of 1,198 outputs
Outputs of similar age
#250,993
of 327,882 outputs
Outputs of similar age from Journal of Hematology & Oncology
#13
of 15 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,882 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.