Title |
Does prostate acinar adenocarcinoma with Gleason Score 3 + 3 = 6 have the potential to metastasize?
|
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Published in |
Diagnostic Pathology, October 2014
|
DOI | 10.1186/s13000-014-0190-z |
Pubmed ID | |
Authors |
Rodolfo Montironi, Marina Scarpelli, Roberta Mazzucchelli, Antonio Lopez-Beltran, Matteo Santoni, Alberto Briganti, Francesco Montorsi, Liang Cheng |
Abstract |
BackgroundThere is a worldwide debate involving clinicians, uropathologists as well as patients and their families on whether Gleason score 6 adenocarcinoma should be labelled as cancer.Case descriptionWe report a case of man diagnosed with biopsy Gleason score 6 acinar adenocarcinoma and classified as low risk (based on a PSA of 5 ng/mL and stage cT2a) whose radical prostatectomy specimen initially showed organ confined Gleason score 3¿+¿3¿=¿6, WHO nuclear grade 3, acinar adenocarcinoma with lymphovascular invasion and secondary deposit in a periprostatic lymph node. When deeper sections were cut to the point that almost all the slice present in the paraffin block was sectioned, a small tumor area (<5% of the whole tumor) of Gleason pattern 4 (poorly formed glands) was found in an extraprostatic position.ConclusionThe epilogue was that the additional finding changed the final Gleason score to 3¿+¿3¿=¿6 with tertiary pattern 4 and the stage to pT3a.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_190. |
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Country | Count | As % |
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United States | 1 | 17% |
Mexico | 1 | 17% |
Brazil | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 33% |
Members of the public | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 17% |
Student > Ph. D. Student | 2 | 9% |
Lecturer | 1 | 4% |
Student > Bachelor | 1 | 4% |
Professor > Associate Professor | 1 | 4% |
Other | 1 | 4% |
Unknown | 13 | 57% |
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Computer Science | 2 | 9% |
Agricultural and Biological Sciences | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 15 | 65% |