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Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model

Overview of attention for article published in Particle and Fibre Toxicology, October 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#28 of 345)
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
twitter
4 tweeters
patent
1 patent

Citations

dimensions_citation
67 Dimensions

Readers on

mendeley
116 Mendeley
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Title
Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
Published in
Particle and Fibre Toxicology, October 2014
DOI 10.1186/s12989-014-0056-2
Pubmed ID
Authors

Ali Kermanizadeh, Mille L hr, Martin Roursgaard, Simon Messner, Patrina Gunness, Jens M Kelm, Peter Møller, Vicki Stone, Steffen Loft

Abstract

BackgroundThe liver has a crucial role in metabolic homeostasis as well as being the principal detoxification centre of the body, removing xenobiotics and waste products which could potentially include some nanomaterials (NM). With the ever increasing public and occupational exposure associated with accumulative production of nanomaterials, there is an urgent need to consider the possibility of detrimental health consequences of engineered NM exposure. It has been shown that exposure via inhalation, intratracheal instillation or ingestion can result in NM translocation to the liver. Traditional in vitro or ex vivo hepatic nanotoxicology models are often limiting and/or troublesome (i.e. reduced metabolism enzymes, lacking important cell populations, unstable with very high variability, etc.).MethodsIn order to rectify these issues and for the very first time we have utilised a 3D human liver microtissue model to investigate the toxicological effects associated with a single or multiple exposure of a panel of engineered NMs (Ag, ZnO, MWCNT and a positively charged TiO2).ResultsHere we demonstrate that the repeated exposure of the NMs is more damaging to the liver tissue as in comparison to a single exposure with the adverse effects more significant following treatment with the Ag and ZnO as compared with the TiO2 and MWCNT NMs (in terms of cytotoxicity, cytokine secretion, lipid peroxidation and genotoxicity).ConclusionsOverall, this study demonstrates that the human microtissue model utilised herein is an excellent candidate for replacement of traditional in vitro single cell hepatic models and further progression of liver nanotoxicology.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Germany 1 <1%
France 1 <1%
Unknown 113 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 25%
Student > Master 22 19%
Researcher 18 16%
Student > Bachelor 12 10%
Other 9 8%
Other 12 10%
Unknown 14 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 17%
Pharmacology, Toxicology and Pharmaceutical Science 18 16%
Biochemistry, Genetics and Molecular Biology 16 14%
Medicine and Dentistry 10 9%
Engineering 8 7%
Other 22 19%
Unknown 22 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2017.
All research outputs
#828,702
of 11,799,729 outputs
Outputs from Particle and Fibre Toxicology
#28
of 345 outputs
Outputs of similar age
#19,272
of 212,340 outputs
Outputs of similar age from Particle and Fibre Toxicology
#3
of 21 outputs
Altmetric has tracked 11,799,729 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 345 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,340 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.