Title |
Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans
|
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Published in |
BMC Research Notes, July 2014
|
DOI | 10.1186/1756-0500-7-427 |
Pubmed ID | |
Authors |
Simone Onur, Petra Niklowitz, Gunnar Jacobs, Ute Nöthlings, Wolfgang Lieb, Thomas Menke, Frank Döring |
Abstract |
The reduced form of Coenzyme Q10 (CoQ10), ubiquinol (Q10H2), serves as a potent antioxidant in mitochondria and lipid membranes. There is evidence that Q10H2 protects against oxidative events in lipids, proteins and DNA. Serum gamma-glutamyltransferase (GGT) activity is associated with cardiovascular diseases. In a physiological range, activity of GGT is a potential early and sensitive marker of inflammation and oxidative stress.In this study, we first examined the relationship between CoQ10 status and serum GGT activity in 416 healthy participants between 19 and 62 years of age in a cross-sectional study (cohort I). In the second step, 53 healthy males (21-48 years of age; cohort II) underwent a 14-day Q10H2 supplementation (150 mg/d) to evaluate the effect of Q10H2 supplementation on serum GGT activity and GGT1 gene expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Russia | 3 | 30% |
Unknown | 7 | 70% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 90% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 12 | 22% |
Student > Bachelor | 8 | 15% |
Other | 6 | 11% |
Student > Postgraduate | 4 | 7% |
Student > Ph. D. Student | 4 | 7% |
Other | 4 | 7% |
Unknown | 16 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 19% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Agricultural and Biological Sciences | 5 | 9% |
Nursing and Health Professions | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 7 | 13% |
Unknown | 18 | 33% |