Title |
Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology
|
---|---|
Published in |
BMC Cancer, October 2014
|
DOI | 10.1186/1471-2407-14-778 |
Pubmed ID | |
Authors |
Emily A Vucic, Kelsie L Thu, Larissa A Pikor, Katey SS Enfield, John Yee, John C English, Calum E MacAulay, Stephen Lam, Igor Jurisica, Wan L Lam |
Abstract |
Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on smoking status, suggesting divergent mechanisms underlie tumorigenesis in smokers and non-smokers. MicroRNAs (miRNAs) are integral contributors to tumorigenesis and mediate biological responses to smoking. Based on the hypothesis that smoking-specific miRNA differences in lung adenocarcinomas reflect distinct tumorigenic processes selected by different smoking and non-smoking environments, we investigated the contribution of miRNA disruption to lung tumor biology and patient outcome in the context of smoking status. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 40% |
Scientists | 2 | 40% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 33% |
Student > Master | 8 | 16% |
Student > Ph. D. Student | 7 | 14% |
Student > Bachelor | 4 | 8% |
Other | 3 | 6% |
Other | 5 | 10% |
Unknown | 7 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 24% |
Agricultural and Biological Sciences | 12 | 24% |
Medicine and Dentistry | 9 | 18% |
Immunology and Microbiology | 2 | 4% |
Psychology | 2 | 4% |
Other | 4 | 8% |
Unknown | 10 | 20% |