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Construction of microRNA and transcription factor regulatory network based on gene expression data in cardiomyopathy

Overview of attention for article published in European Journal of Medical Research, October 2014
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Mentioned by

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3 tweeters

Citations

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3 Dimensions

Readers on

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12 Mendeley
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Title
Construction of microRNA and transcription factor regulatory network based on gene expression data in cardiomyopathy
Published in
European Journal of Medical Research, October 2014
DOI 10.1186/s40001-014-0057-5
Pubmed ID
Authors

Lei Wang, Jihua Hu, Haijian Xing, Min Sun, Juanli Wang, Qiang Jian, Hua Yang

Abstract

BackgroundCardiomyopathy is a progressive myocardial disorder. Here, we attempted to reveal the possible mechanism of cardiomyopathy at the transcription level with the roles of microRNAs (miRNAs) and transcription factors (TFs) taken into account.MethodWe firstly identified differentially expressed genes (DEGs) between cardiomyopathy patients and controls with data from the gene expression omnibus (GEO) database. DEGs were associated with the canonical pathways, molecular and cellular functions, physiological system development and function in the Ingenuity Knowledge Base by using the Ingenuity Pathway Analysis (IPA) software. TFs and miRNAs that DEGs significantly enriched were identified and a double-factor regulatory network was constructed.ResultsA total of 1,680 DEGs were identified. The DEGs were enriched for various pathways, with glucocorticoid receptor signaling as the most significant. A double-factor regulatory network was constructed, including seven TFs and two miRNAs. A subnetwork under the regulation of MEF2C and SRF was also constructed to illustrate their regulatory effects on cardiac functions.ConclusionOur results may provide new understanding of cardiomyopathy and may facilitate further therapeutic studies.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 50%
Student > Ph. D. Student 2 17%
Unspecified 1 8%
Student > Bachelor 1 8%
Student > Postgraduate 1 8%
Other 0 0%
Unknown 1 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 33%
Medicine and Dentistry 2 17%
Agricultural and Biological Sciences 2 17%
Unspecified 1 8%
Nursing and Health Professions 1 8%
Other 0 0%
Unknown 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2014.
All research outputs
#14,312,548
of 21,321,698 outputs
Outputs from European Journal of Medical Research
#249
of 516 outputs
Outputs of similar age
#144,810
of 252,347 outputs
Outputs of similar age from European Journal of Medical Research
#15
of 29 outputs
Altmetric has tracked 21,321,698 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 516 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,347 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.