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X Demographics
Mendeley readers
| Title |
Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
|
|---|---|
| Published in |
BMC Biology, October 2014
|
| DOI | 10.1186/s12915-014-0082-4 |
| Pubmed ID | |
| Authors |
Alba Luengo, Lucas B Sullivan, Matthew G Vander Heiden |
| Abstract |
Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of metformin use in the clinic, its molecular mechanism of action remains controversial. In a recent issue of Cancer & Metabolism, Andrzejewski et al. present evidence that metformin acts directly on mitochondria to inhibit complex I and limits the ability of cancer cells to cope with energetic stress. Here, we discuss evidence that supports the role of metformin as a cancer therapeutic. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Spain | 1 | 17% |
| Singapore | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Scientists | 1 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| South Africa | 1 | <1% |
| Czechia | 1 | <1% |
| China | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 126 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 20% |
| Researcher | 19 | 15% |
| Student > Master | 18 | 14% |
| Student > Bachelor | 15 | 11% |
| Student > Doctoral Student | 6 | 5% |
| Other | 20 | 15% |
| Unknown | 27 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 32 | 24% |
| Medicine and Dentistry | 29 | 22% |
| Agricultural and Biological Sciences | 29 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Environmental Science | 2 | 2% |
| Other | 7 | 5% |
| Unknown | 26 | 20% |