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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
|
|---|---|
| Published in |
Cell & Bioscience, August 2017
|
| DOI | 10.1186/s13578-017-0165-3 |
| Pubmed ID | |
| Authors |
Hamoud Al-Khallaf |
| Abstract |
Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism are distinct from those of isoform 3. It will also explain why, unlike 1 and 2, mutations in isoform 3 in tumor are not likely to be driver ones. A model explaining two important features of isocitrate dehydrogenases 1 and 2 mutations, their dominant negative effect and their mutual exclusivity, will be provided. The importance of targeting these mutations and the possibility of augmenting such therapy by targeting other cancer-related pathways will also be discussed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 190 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 20% |
| Student > Bachelor | 24 | 13% |
| Researcher | 22 | 12% |
| Student > Master | 18 | 9% |
| Student > Doctoral Student | 5 | 3% |
| Other | 16 | 8% |
| Unknown | 67 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 42 | 22% |
| Medicine and Dentistry | 18 | 9% |
| Agricultural and Biological Sciences | 17 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
| Neuroscience | 8 | 4% |
| Other | 24 | 13% |
| Unknown | 72 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2017.
All research outputs
#14,083,701
of 23,007,053 outputs
Outputs from Cell & Bioscience
#281
of 944 outputs
Outputs of similar age
#170,044
of 317,580 outputs
Outputs of similar age from Cell & Bioscience
#5
of 9 outputs
Altmetric has tracked 23,007,053 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 944 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,580 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.