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Mendeley readers
Attention Score in Context
| Title |
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
|
|---|---|
| Published in |
Molecular Neurodegeneration, October 2014
|
| DOI | 10.1186/1750-1326-9-42 |
| Pubmed ID | |
| Authors |
Scott A Yuzwa, Xiaoyang Shan, Bryan A Jones, Gang Zhao, Melissa L Woodward, Xiaojing Li, Yanping Zhu, Ernest J McEachern, Michael A Silverman, Neil V Watson, Cheng-Xin Gong, David J Vocadlo |
| Abstract |
Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmarks of Alzheimer's disease (AD). Increasing the quantity of the O-linked N-acetylglucosamine (O-GlcNAc) post-translation modification of nuclear and cytoplasmic proteins slows neurodegeneration and blocks the formation of NFTs in a tauopathy mouse model. It remains unknown, however, if O-GlcNAc can influence the formation of amyloid plaques in the presence of tau pathology. |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 107 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 24% |
| Student > Ph. D. Student | 22 | 20% |
| Student > Bachelor | 17 | 15% |
| Student > Master | 11 | 10% |
| Other | 4 | 4% |
| Other | 7 | 6% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 25% |
| Agricultural and Biological Sciences | 17 | 15% |
| Neuroscience | 14 | 13% |
| Chemistry | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Other | 14 | 13% |
| Unknown | 24 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2023.
All research outputs
#5,135,790
of 24,682,395 outputs
Outputs from Molecular Neurodegeneration
#599
of 929 outputs
Outputs of similar age
#55,772
of 265,877 outputs
Outputs of similar age from Molecular Neurodegeneration
#5
of 15 outputs
Altmetric has tracked 24,682,395 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 929 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,877 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.