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Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

Overview of attention for article published in Molecular Neurodegeneration, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent
facebook
1 Facebook page

Citations

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74 Dimensions

Readers on

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88 Mendeley
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Title
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
Published in
Molecular Neurodegeneration, January 2014
DOI 10.1186/1750-1326-9-42
Pubmed ID
Authors

Scott A Yuzwa, Xiaoyang Shan, Bryan A Jones, Gang Zhao, Melissa L Woodward, Xiaojing Li, Yanping Zhu, Ernest J McEachern, Michael A Silverman, Neil V Watson, Cheng-Xin Gong, David J Vocadlo

Abstract

Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmarks of Alzheimer's disease (AD). Increasing the quantity of the O-linked N-acetylglucosamine (O-GlcNAc) post-translation modification of nuclear and cytoplasmic proteins slows neurodegeneration and blocks the formation of NFTs in a tauopathy mouse model. It remains unknown, however, if O-GlcNAc can influence the formation of amyloid plaques in the presence of tau pathology.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
United States 1 1%
Denmark 1 1%
Unknown 85 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 31%
Student > Ph. D. Student 14 16%
Student > Bachelor 14 16%
Student > Master 9 10%
Other 5 6%
Other 8 9%
Unknown 11 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 24 27%
Agricultural and Biological Sciences 17 19%
Neuroscience 10 11%
Medicine and Dentistry 6 7%
Chemistry 6 7%
Other 13 15%
Unknown 12 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2020.
All research outputs
#4,567,822
of 16,775,501 outputs
Outputs from Molecular Neurodegeneration
#392
of 665 outputs
Outputs of similar age
#59,868
of 236,309 outputs
Outputs of similar age from Molecular Neurodegeneration
#6
of 11 outputs
Altmetric has tracked 16,775,501 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 665 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.