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Alpha-synuclein biology in Lewy body diseases

Overview of attention for article published in Alzheimer's Research & Therapy, October 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
3 X users
patent
3 patents
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
285 Dimensions

Readers on

mendeley
625 Mendeley
citeulike
1 CiteULike
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Title
Alpha-synuclein biology in Lewy body diseases
Published in
Alzheimer's Research & Therapy, October 2014
DOI 10.1186/s13195-014-0073-2
Pubmed ID
Authors

Woojin Scott Kim, Katarina Kågedal, Glenda M Halliday

Abstract

α-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understanding a group of neurodegenerative disorders called α-synucleinopathies, which are characterized by the presence of aggregated α-synuclein intracellularly. Primary α-synucleinopathies include Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, with α-synuclein also found secondarily in a number of other diseases, including Alzheimer's disease. Understanding how α-synuclein aggregates form in these different disorders is important for the understanding of its pathogenesis in Lewy body diseases. PD is the most prevalent of the α-synucleinopathies and much of the initial research on α-synuclein Lewy body pathology was based on PD but is also relevant to Lewy bodies in other diseases (dementia with Lewy bodies and Alzheimer's disease). Polymorphism and mutation studies of SNCA, the gene that encodes α-synuclein, provide much evidence for a causal link between α-synuclein and PD. Among the primary α-synucleinopathies, multiple system atrophy is unique in that α-synuclein deposition occurs in oligodendrocytes rather than neurons. It is unclear whether α-synuclein originates from oligodendrocytes or whether it is transmitted somehow from neurons. α-Synuclein exists as a natively unfolded monomer in the cytosol, but in the presence of lipid membranes it is thought to undergo a conformational change to a folded α-helical secondary structure that is prone to forming dimers and oligomers. Posttranslational modification of α-synuclein, such as phosphorylation, ubiquitination and nitration, has been widely implicated in α-synuclein aggregation process and neurotoxicity. Recent studies using animal and cell models, as well as autopsy studies of patients with neuron transplants, provided compelling evidence for prion-like propagation of α-synuclein. This observation has implications for therapeutic strategies, and much recent effort is focused on developing antibodies that target extracellular α-synuclein.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 625 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
United Kingdom 2 <1%
India 1 <1%
Unknown 619 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 120 19%
Student > Bachelor 109 17%
Student > Master 86 14%
Researcher 61 10%
Student > Postgraduate 32 5%
Other 79 13%
Unknown 138 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 105 17%
Neuroscience 99 16%
Agricultural and Biological Sciences 97 16%
Medicine and Dentistry 59 9%
Pharmacology, Toxicology and Pharmaceutical Science 24 4%
Other 73 12%
Unknown 168 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2023.
All research outputs
#997,315
of 23,578,918 outputs
Outputs from Alzheimer's Research & Therapy
#125
of 1,301 outputs
Outputs of similar age
#11,820
of 261,405 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#1
of 16 outputs
Altmetric has tracked 23,578,918 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,301 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,405 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.