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Alpha-synuclein biology in Lewy body diseases

Overview of attention for article published in Alzheimer's Research & Therapy, October 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
3 tweeters
patent
3 patents
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
228 Dimensions

Readers on

mendeley
560 Mendeley
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Title
Alpha-synuclein biology in Lewy body diseases
Published in
Alzheimer's Research & Therapy, October 2014
DOI 10.1186/s13195-014-0073-2
Pubmed ID
Authors

Woojin Scott Kim, Katarina Kågedal, Glenda M Halliday

Abstract

α-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understanding a group of neurodegenerative disorders called α-synucleinopathies, which are characterized by the presence of aggregated α-synuclein intracellularly. Primary α-synucleinopathies include Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, with α-synuclein also found secondarily in a number of other diseases, including Alzheimer's disease. Understanding how α-synuclein aggregates form in these different disorders is important for the understanding of its pathogenesis in Lewy body diseases. PD is the most prevalent of the α-synucleinopathies and much of the initial research on α-synuclein Lewy body pathology was based on PD but is also relevant to Lewy bodies in other diseases (dementia with Lewy bodies and Alzheimer's disease). Polymorphism and mutation studies of SNCA, the gene that encodes α-synuclein, provide much evidence for a causal link between α-synuclein and PD. Among the primary α-synucleinopathies, multiple system atrophy is unique in that α-synuclein deposition occurs in oligodendrocytes rather than neurons. It is unclear whether α-synuclein originates from oligodendrocytes or whether it is transmitted somehow from neurons. α-Synuclein exists as a natively unfolded monomer in the cytosol, but in the presence of lipid membranes it is thought to undergo a conformational change to a folded α-helical secondary structure that is prone to forming dimers and oligomers. Posttranslational modification of α-synuclein, such as phosphorylation, ubiquitination and nitration, has been widely implicated in α-synuclein aggregation process and neurotoxicity. Recent studies using animal and cell models, as well as autopsy studies of patients with neuron transplants, provided compelling evidence for prion-like propagation of α-synuclein. This observation has implications for therapeutic strategies, and much recent effort is focused on developing antibodies that target extracellular α-synuclein.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 560 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
United Kingdom 2 <1%
India 1 <1%
Unknown 554 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 114 20%
Student > Bachelor 104 19%
Student > Master 80 14%
Researcher 54 10%
Student > Postgraduate 31 6%
Other 81 14%
Unknown 96 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 96 17%
Biochemistry, Genetics and Molecular Biology 95 17%
Neuroscience 94 17%
Medicine and Dentistry 55 10%
Chemistry 23 4%
Other 74 13%
Unknown 123 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2021.
All research outputs
#1,077,517
of 21,321,610 outputs
Outputs from Alzheimer's Research & Therapy
#128
of 1,098 outputs
Outputs of similar age
#14,419
of 252,668 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#2
of 21 outputs
Altmetric has tracked 21,321,610 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,098 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,668 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.