Title |
Effect of Poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model
|
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Published in |
Journal of Orthopaedic Surgery and Research, March 2014
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DOI | 10.1186/1749-799x-9-12 |
Pubmed ID | |
Authors |
Soung-Yon Kim, Soo-Won Chae, Juneyoung Lee |
Abstract |
In vivo studies showing the effects of biologic healing-promoting factors on tendon-to-bone healing after rotator cuff repair have focused only on biologic healing-promoting factors and have not taken into consideration the effect of the carrier vehicle. Moreover, most studies have evaluated the healing process using different carrier vehicles, each of which may have specific effects on tendon healing. This may explain the large variability seen in outcomes in research studies. In this study, we investigated the effects of Poloxamer 407 as a carrier vehicle on rotator cuff healing at the repair site and compared it with those of a collagen sponge, which is a commonly used carrier vehicle. |
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