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Sucrose stabilization of Respiratory Syncytial Virus (RSV) during nebulization and experimental infection

Overview of attention for article published in BMC Research Notes, March 2014
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1 tweeter

Citations

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29 Mendeley
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Title
Sucrose stabilization of Respiratory Syncytial Virus (RSV) during nebulization and experimental infection
Published in
BMC Research Notes, March 2014
DOI 10.1186/1756-0500-7-158
Pubmed ID
Authors

Drew D Grosz, Albert van Geelen, Jack M Gallup, Shannon J Hostetter, Rachel J Derscheid, Mark R Ackermann

Abstract

Respiratory syncytial virus (RSV) is a common respiratory pathogen that can cause severe pneumonia. In vivo studies of RSV can be difficult due to variation in viral infection and disease severity in some animal models. Factors that may contribute to the variation are decreases in viral titer due to preparation and storage and method of virus administration. Nebulization is one method of RSV administration that provides even distribution of virus to all lung lobes; however, the exact quantity of the virus killed by nebulization is not defined. To test the hypothesis that sucrose enhances RSV stability and infectivity, a series of in vitro experiments were conducted with RSV strain Memphis 37 stored at varying concentrations (0%, 3%, 5%, 8%, 10%, 15%, and 20%) of sucrose as a possible cryo- and nebulization protectant. The optimal in vitro concentration was then assessed in vivo in a lamb model.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 17%
Researcher 4 14%
Professor > Associate Professor 3 10%
Student > Master 3 10%
Student > Bachelor 2 7%
Other 4 14%
Unknown 8 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 17%
Agricultural and Biological Sciences 4 14%
Medicine and Dentistry 3 10%
Engineering 2 7%
Immunology and Microbiology 1 3%
Other 3 10%
Unknown 11 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2014.
All research outputs
#11,135,223
of 12,519,627 outputs
Outputs from BMC Research Notes
#2,338
of 2,804 outputs
Outputs of similar age
#188,606
of 229,959 outputs
Outputs of similar age from BMC Research Notes
#19
of 23 outputs
Altmetric has tracked 12,519,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,804 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,959 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.