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Influence of external calcium and thapsigargin on the uptake of polystyrene beads by the macrophage-like cell lines U937 and MH-S

Overview of attention for article published in BMC Pharmacology and Toxicology, March 2014
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Title
Influence of external calcium and thapsigargin on the uptake of polystyrene beads by the macrophage-like cell lines U937 and MH-S
Published in
BMC Pharmacology and Toxicology, March 2014
DOI 10.1186/2050-6511-15-16
Pubmed ID
Authors

Ebru Diler, Marion Schwarz, Ruth Nickels, Michael D Menger, Christoph Beisswenger, Carola Meier, Thomas Tschernig

Abstract

Macrophages are equipped with several receptors for the recognition of foreign particles and pathogens. Upon binding to these receptors, particles become internalized. An interaction of particles with macrophage surface receptors is accompanied by an increase in cytosolic calcium concentration. This calcium is provided by intracellular stores and also by an influx of external calcium upon activation of the calcium channels. Nevertheless, the role of calcium in phagocytosis remains controversial. Some researchers postulate the necessity of calcium in Fc-receptor-mediated phagocytosis and a calcium-independent phagocytosis of complement opsonized particles. Others refute the need for calcium in Fc-receptor-mediated phagocytosis by macrophages.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 7%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 22%
Student > Ph. D. Student 6 22%
Student > Bachelor 3 11%
Professor 3 11%
Student > Master 3 11%
Other 3 11%
Unknown 3 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 22%
Agricultural and Biological Sciences 5 19%
Immunology and Microbiology 5 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Medicine and Dentistry 2 7%
Other 2 7%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2014.
All research outputs
#20,241,019
of 22,768,097 outputs
Outputs from BMC Pharmacology and Toxicology
#365
of 439 outputs
Outputs of similar age
#191,578
of 223,427 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#15
of 15 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 439 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,427 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.