Title |
Correlation between the genomic o454-nlpD region polymorphisms, virulence gene equipment and phylogenetic group of extraintestinal Escherichia coli (ExPEC) enables pathotyping irrespective of host, disease and source of isolation
|
---|---|
Published in |
Gut Pathogens, September 2014
|
DOI | 10.1186/s13099-014-0037-x |
Pubmed ID | |
Authors |
Christa Ewers, Flavia Dematheis, Haritha Devi Singamaneni, Nishant Nandanwar, Angelika Fruth, Ines Diehl, Torsten Semmler, Lothar H Wieler |
Abstract |
The mutS-rpoS intergenic region in E. coli displays a mosaic structure which revealed pathotype specific patterns. To assess the importance of this region as a surrogate marker for the identification of highly virulent extraintestinal pathogenic E. coli (ExPEC) strains we aimed to: (i) characterize the genetic diversity of the mutS gene and the o454-nlpD genomic region among 510 E. coli strains from animals and humans; (ii) delineate associations between the polymorphism of this region and features such as phylogenetic background of E. coli, pathotype, host species, clinical condition, serogroup and virulence associated genes (VAG)s; and (iii) identify the most important VAGs for classification of the o454-nlpD region. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 28% |
Student > Master | 3 | 17% |
Other | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Student > Bachelor | 2 | 11% |
Other | 2 | 11% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 28% |
Immunology and Microbiology | 4 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Environmental Science | 1 | 6% |
Social Sciences | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 22% |