Title |
A new model of time scheme for progression of colorectal cancer
|
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Published in |
BMC Systems Biology, October 2014
|
DOI | 10.1186/1752-0509-8-s3-s2 |
Pubmed ID | |
Authors |
Shuhao Sun, Fima Klebaner, Tianhai Tian |
Abstract |
tumourigenesis can be regarded as an evolutionary process, in which the transformation of a normal cell into a tumour cell involves a number of limiting genetic and epigenetic events. To study the progression process, time schemes have been proposed for studying the process of colorectal cancer based on extensive clinical investigations. Moreover, a number of mathematical models have been designed to describe this evolutionary process. These models assumed that the mutation rate of genes is constant during different stages. However, it has been pointed that the subsequent driver mutations appear faster than the previous ones and the cumulative time to have more driver mutations grows with the growing number of gene mutations. Thus it is still a challenge to calculate the time when the first mutation occurs and to determine the influence of tumour size on the mutation rate. |
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France | 1 | 100% |
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Mendeley readers
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Demographic breakdown
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Student > Bachelor | 4 | 19% |
Researcher | 4 | 19% |
Student > Ph. D. Student | 2 | 10% |
Professor | 2 | 10% |
Student > Master | 2 | 10% |
Other | 1 | 5% |
Unknown | 6 | 29% |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Linguistics | 1 | 5% |
Computer Science | 1 | 5% |
Other | 3 | 14% |
Unknown | 5 | 24% |