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A young female presenting with unilateral sacroiliitis following dengue virus infection: a case report

Overview of attention for article published in Journal of Medical Case Reports, November 2017
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Title
A young female presenting with unilateral sacroiliitis following dengue virus infection: a case report
Published in
Journal of Medical Case Reports, November 2017
DOI 10.1186/s13256-017-1483-0
Pubmed ID
Authors

W. D. Jayamali, H. M. M. T. B. Herath, Aruna Kulatunga

Abstract

Dengue is a common arthropod-borne viral infection in Sri Lanka which is spread by the mosquitos of the genus Aedes. The clinical features of dengue include high-grade fever associated with arthralgia and myalgia. However, dengue virus is not considered an arthritogenic virus. We report a case of a previously healthy young female who presented with imaging-confirmed right-sided sacroiliitis 10 days after developing dengue fever. This is the first reported case that shows a possible link between dengue infection and development of arthritis. A 14-year-old Sri Lankan female presented to our medical unit with right buttock and hip pain of 3 weeks' duration. She had serologically confirmed dengue infection 10 days prior to the onset of buttock pain. A clinical examination revealed features of right sacroiliitis. An X-ray of her sacroiliac joint showed joint space widening and reactive bone changes. Magnetic resonance imaging of her pelvis and sacroiliac joint confirmed the diagnosis of acute sacroiliitis. She had an erythrocyte sedimentation rate of 110 mm first hour with a normal C-reactive protein. Her human leukocyte antigen-B27, rheumatoid factor, antinuclear antibody, chikungunya antibody, hepatitis serology, Brucella serology, and tuberculin skin test were negative. She was treated with nonsteroidal anti-inflammatory drugs and showed gradual improvement. After excluding possible causes for sacroiliitis, we postulated that sacroiliitis in the index case could have been caused or triggered by dengue virus infection. However there is a possibility that the sacroiliitis merely coincided with the dengue virus infection. This case illustrates the possibility that dengue virus could have a link with the development of arthritis in the same manner as other arthritogenic viruses; possible mechanisms for this include direct invasion of the synovium and the joint tissue by the virus, immune complex formation and deposition in the joint tissue, and immune dysregulation. Further studies are needed in this field to gain more knowledge, as dengue infection is highly prevalent in Sri Lanka.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 64 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 14%
Student > Bachelor 8 13%
Student > Postgraduate 8 13%
Researcher 8 13%
Student > Doctoral Student 4 6%
Other 10 16%
Unknown 17 27%
Readers by discipline Count As %
Medicine and Dentistry 22 34%
Nursing and Health Professions 5 8%
Biochemistry, Genetics and Molecular Biology 4 6%
Agricultural and Biological Sciences 4 6%
Economics, Econometrics and Finance 2 3%
Other 8 13%
Unknown 19 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2017.
All research outputs
#20,451,228
of 23,007,053 outputs
Outputs from Journal of Medical Case Reports
#3,511
of 3,946 outputs
Outputs of similar age
#286,849
of 329,160 outputs
Outputs of similar age from Journal of Medical Case Reports
#66
of 70 outputs
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