Title |
Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteins
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Published in |
BMC Cancer, October 2014
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DOI | 10.1186/1471-2407-14-781 |
Pubmed ID | |
Authors |
An Zou, Diana Lambert, Henry Yeh, Ken Yasukawa, Fariba Behbod, Fang Fan, Nikki Cheng |
Abstract |
CXCL1 is a chemotactic cytokine shown to regulate breast cancer progression and chemo-resistance. However, the prognostic significance of CXCL1 expression in breast cancer has not been fully characterized. Fibroblasts are important cellular components of the breast tumor microenvironment, and recent studies indicate that this cell type is a potential source of CXCL1 expression in breast tumors. The goal of this study was to further characterize the expression patterns of CXCL1 in breast cancer stroma, determine the prognostic significance of stromal CXCL1 expression, and identify factors affecting stromal CXCL1 expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Argentina | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 71 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 27% |
Researcher | 13 | 18% |
Student > Bachelor | 10 | 14% |
Student > Master | 8 | 11% |
Student > Doctoral Student | 2 | 3% |
Other | 8 | 11% |
Unknown | 13 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 32% |
Biochemistry, Genetics and Molecular Biology | 12 | 16% |
Agricultural and Biological Sciences | 11 | 15% |
Immunology and Microbiology | 4 | 5% |
Computer Science | 2 | 3% |
Other | 6 | 8% |
Unknown | 15 | 20% |