Title |
The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma
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Published in |
BMC Cancer, March 2014
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DOI | 10.1186/1471-2407-14-149 |
Pubmed ID | |
Authors |
Anastasios Stofas, Georgia Levidou, Christina Piperi, Christos Adamopoulos, Georgia Dalagiorgou, Aristotelis Bamias, Alexandra Karadimou, George A Lainakis, Stefanos Papadoukakis, Konstantinos Stravodimos, Meletios-Athanasios Dimopoulos, Efstratios Patsouris, Hariklia Gakiopoulou, Penelope Korkolopoulou |
Abstract |
Chemokine receptor signaling pathways are implicated in the pathobiology of renal cell carcinoma (RCC). However, the clinical relevance of CXCR2 receptor, mediating the effects of all angiogenic chemokines, remains unclear. SOCS (suppressor of cytokine signaling)-3 is a negative regulator of cytokine-driven responses, contributing to interferon-α resistance commonly used to treat advanced RCC with limited information regarding its expression in RCC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 15% |
Other | 2 | 10% |
Student > Bachelor | 2 | 10% |
Student > Master | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 3 | 15% |
Unknown | 6 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 25% |
Agricultural and Biological Sciences | 3 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Immunology and Microbiology | 2 | 10% |
Nursing and Health Professions | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 30% |