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Mendeley readers
Attention Score in Context
| Title |
Expression of P16 in high-risk human papillomavirus related lesions of the uterine cervix in a government hospital, Malaysia
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|---|---|
| Published in |
Diagnostic Pathology, November 2014
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| DOI | 10.1186/s13000-014-0202-z |
| Pubmed ID | |
| Authors |
Purushotham Krishnappa, Ibtisam Binti Mohamad, Yip Jo Lin, Ankur Barua |
| Abstract |
BackgroundCervical cancer is one of the most common cancers affecting women worldwide. It is well established that human papilloma virus (HPV) infection is the prime risk factor in the development of cervical cancer. The current screening and diagnostic tests have limitations in identifying the range of lesions caused by HPV. The current study aims to evaluate the diagnostic value of p16 immunohistochemical (IHC) investigation in high-risk human papillomavirus (HR-HPV) related lesions of the uterine cervix in Hospital Tuanku Jaafar, Seremban, Malaysia.MethodsA total of 75 cases were selected from the records of Pathology services, Hospital Tuanku Ja¿afar, Seremban. The samples were collected in three separate groups (n¿=¿25 per group) as Carcinoma cervix, Carcinoma in situ and Chronic cervicitis. The demographic data of the patients and the representative paraffin blocks were retrieved from Hospital Tuanku Ja¿afar, Seremban. The immunohistochemical staining with p16 and HPV 16 L1 were done on all cases. The staining intensity and density were observed and compared among the three groups of cases.ResultsImmunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cervicitis patients, 72% (18/25) in CIN patients and 100% (25/25) in cervical carcinoma. HPV 16 L1 was positive in 100% (25/25) of cervicitis patients, 96% (24/25) of CIN patients and 40% (10/25) of cervical cancers patients. A chi square test was used to analyze the result and the obtained p value was <0.05.Conclusionp16 expression was strongly observed in cervical cancer and minimally observed in cervicitis. Thus indicating p16 immunohistochemistry investigations can aid in diagnosing the different categories of cervical lesions into benign, insitu and malignant.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_202. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 24% |
| Student > Master | 8 | 15% |
| Student > Doctoral Student | 4 | 7% |
| Student > Postgraduate | 4 | 7% |
| Researcher | 3 | 6% |
| Other | 6 | 11% |
| Unknown | 16 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 31% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Nursing and Health Professions | 3 | 6% |
| Immunology and Microbiology | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 18 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2014.
All research outputs
#18,382,900
of 22,769,322 outputs
Outputs from Diagnostic Pathology
#757
of 1,123 outputs
Outputs of similar age
#186,454
of 260,561 outputs
Outputs of similar age from Diagnostic Pathology
#39
of 49 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,123 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.