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It is time for top-down venomics

Overview of attention for article published in Journal of Venomous Animals and Toxins including Tropical Diseases, October 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

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35 Dimensions

Readers on

mendeley
68 Mendeley
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Title
It is time for top-down venomics
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases, October 2017
DOI 10.1186/s40409-017-0135-6
Pubmed ID
Authors

Rafael D. Melani, Fabio C. S. Nogueira, Gilberto B. Domont

Abstract

The protein composition of animal venoms is usually determined by peptide-centric proteomics approaches (bottom-up proteomics). However, this technique cannot, in most cases, distinguish among toxin proteoforms, herein called toxiforms, because of the protein inference problem. Top-down proteomics (TDP) analyzes intact proteins without digestion and provides high quality data to identify and characterize toxiforms. Denaturing top-down proteomics is the most disseminated subarea of TDP, which performs qualitative and quantitative analyzes of proteoforms up to ~30 kDa in high-throughput and automated fashion. On the other hand, native top-down proteomics provides access to information on large proteins (> 50 kDA) and protein interactions preserving non-covalent bonds and physiological complex stoichiometry. The use of native and denaturing top-down venomics introduced novel and useful techniques to toxinology, allowing an unprecedented characterization of venom proteins and protein complexes at the toxiform level. The collected data contribute to a deep understanding of venom natural history, open new possibilities to study the toxin evolution, and help in the development of better biotherapeutics.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 16%
Student > Ph. D. Student 10 15%
Student > Bachelor 10 15%
Researcher 7 10%
Student > Doctoral Student 3 4%
Other 12 18%
Unknown 15 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 29%
Agricultural and Biological Sciences 12 18%
Chemistry 8 12%
Engineering 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 7 10%
Unknown 16 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2021.
All research outputs
#8,264,793
of 25,382,440 outputs
Outputs from Journal of Venomous Animals and Toxins including Tropical Diseases
#175
of 539 outputs
Outputs of similar age
#124,908
of 336,554 outputs
Outputs of similar age from Journal of Venomous Animals and Toxins including Tropical Diseases
#1
of 5 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 539 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,554 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them