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Stress amplifies sex differences in primate prefrontal profiles of gene expression

Overview of attention for article published in Biology of Sex Differences, November 2017
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Title
Stress amplifies sex differences in primate prefrontal profiles of gene expression
Published in
Biology of Sex Differences, November 2017
DOI 10.1186/s13293-017-0157-3
Pubmed ID
Authors

Alex G. Lee, Megan Hagenauer, Devin Absher, Kathleen E. Morrison, Tracy L. Bale, Richard M. Myers, Stanley J. Watson, Huda Akil, Alan F. Schatzberg, David M. Lyons

Abstract

Stress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress coping, cognitive control, and emotion. Here, we investigate sex differences and stress effects on prefrontal cortical profiles of gene expression in squirrel monkey adults. Dorsolateral, ventrolateral, and ventromedial prefrontal cortical regions from 18 females and 12 males were collected after stress or no-stress treatment conditions. Gene expression profiles were acquired using HumanHT-12v4.0 Expression BeadChip arrays adapted for squirrel monkeys. Extensive variation between prefrontal cortical regions was discerned in the expression of numerous autosomal and sex chromosome genes. Robust sex differences were also identified across prefrontal cortical regions in the expression of mostly autosomal genes. Genes with increased expression in females compared to males were overrepresented in mitogen-activated protein kinase and neurotrophin signaling pathways. Many fewer genes with increased expression in males compared to females were discerned, and no molecular pathways were identified. Effect sizes for sex differences were greater in stress compared to no-stress conditions for ventromedial and ventrolateral prefrontal cortical regions but not dorsolateral prefrontal cortex. Stress amplifies sex differences in gene expression profiles for prefrontal cortical regions involved in stress coping and emotion regulation. Results suggest molecular targets for new treatments of stress disorders in human mental health.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 24%
Student > Master 6 15%
Researcher 4 10%
Professor 2 5%
Student > Doctoral Student 2 5%
Other 5 12%
Unknown 12 29%
Readers by discipline Count As %
Psychology 8 20%
Agricultural and Biological Sciences 7 17%
Neuroscience 7 17%
Decision Sciences 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 2 5%
Unknown 15 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2018.
All research outputs
#13,913,470
of 24,266,964 outputs
Outputs from Biology of Sex Differences
#294
of 524 outputs
Outputs of similar age
#160,631
of 333,583 outputs
Outputs of similar age from Biology of Sex Differences
#5
of 7 outputs
Altmetric has tracked 24,266,964 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 524 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.